European Cooperative Acute Stroke Study-4: Extending the time for thrombolysis in emergency neurological deficits ECASS-4: ExTEND.
Identifieur interne : 001F59 ( Main/Exploration ); précédent : 001F58; suivant : 001F60European Cooperative Acute Stroke Study-4: Extending the time for thrombolysis in emergency neurological deficits ECASS-4: ExTEND.
Auteurs : Hemasse Amiri [Allemagne] ; Erich Bluhmki [Allemagne] ; Martin Bendszus [Allemagne] ; Christoph C. Eschenfelder [Allemagne] ; Geoffrey A. Donnan [Australie] ; Didier Leys [France] ; Carlos Molina [Espagne] ; Peter A. Ringleb [Allemagne] ; Peter D. Schellinger [Allemagne] ; Stefan Schwab [Allemagne] ; Danilo Toni [Italie] ; Nils Wahlgren [Suède] ; Werner Hacke [Allemagne]Source :
- International journal of stroke : official journal of the International Stroke Society [ 1747-4949 ] ; 2016.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (traitement médicamenteux), Activateur tissulaire du plasminogène (administration et posologie), Activateur tissulaire du plasminogène (usage thérapeutique), Administration par voie intraveineuse, Facteurs temps, Humains, Imagerie par résonance magnétique, Méthode en double aveugle, Neuroimagerie, Protocoles cliniques (normes), Résultat thérapeutique, Traitement thrombolytique ().
- MESH :
- administration et posologie : Activateur tissulaire du plasminogène.
- normes : Protocoles cliniques.
- traitement médicamenteux : Accident vasculaire cérébral.
- usage thérapeutique : Activateur tissulaire du plasminogène.
- Administration par voie intraveineuse, Facteurs temps, Humains, Imagerie par résonance magnétique, Méthode en double aveugle, Neuroimagerie, Résultat thérapeutique, Traitement thrombolytique.
English descriptors
- KwdEn :
- Administration, Intravenous, Clinical Protocols (standards), Double-Blind Method, Humans, Magnetic Resonance Imaging, Neuroimaging, Stroke (drug therapy), Thrombolytic Therapy (methods), Time Factors, Tissue Plasminogen Activator (administration & dosage), Tissue Plasminogen Activator (therapeutic use), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Tissue Plasminogen Activator.
- drug therapy : Stroke.
- methods : Thrombolytic Therapy.
- standards : Clinical Protocols.
- chemical , therapeutic use : Tissue Plasminogen Activator.
- Administration, Intravenous, Double-Blind Method, Humans, Magnetic Resonance Imaging, Neuroimaging, Time Factors, Treatment Outcome.
Abstract
Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is an effective and approved therapy for acute ischemic stroke within 4.5 h of onset except for USA, Canada, Croatia, and Moldovia with a current 3 h label. We hypothesized that ischemic stroke patients selected with significant penumbral mismatch on magnetic resonance imaging (MRI) at 4.5-9 h after onset of stroke will have improved clinical outcomes when given intravenous rt-PA (alteplase) compared to placebo.
DOI: 10.1177/1747493015620805
PubMed: 26783318
Affiliations:
- Allemagne, Australie, Espagne, France, Italie, Suède
- Bade-Wurtemberg, Bavière, Catalogne, District de Karlsruhe, District de Moyenne-Franconie, Hauts-de-France, Latium, Nord-Pas-de-Calais, Victoria (État)
- Barcelone, Erlangen, Heidelberg, Lille, Melbourne, Rome
- Université de Melbourne
Links toward previous steps (curation, corpus...)
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Le document en format XML
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last="Amiri">Hemasse Amiri</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany Hemasse.Amiri@med.uni-heidelberg.de.</nlm:affiliation><country wicri:rule="url">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Bluhmki, Erich" sort="Bluhmki, Erich" uniqKey="Bluhmki E" first="Erich" last="Bluhmki">Erich Bluhmki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Statistics, Boehringer Ingelheim, Bieberach, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Statistics, Boehringer Ingelheim, Bieberach</wicri:regionArea><wicri:noRegion>Bieberach</wicri:noRegion><wicri:noRegion>Bieberach</wicri:noRegion><wicri:noRegion>Bieberach</wicri:noRegion></affiliation></author><author><name sortKey="Bendszus, Martin" sort="Bendszus, Martin" uniqKey="Bendszus M" first="Martin" last="Bendszus">Martin Bendszus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuroradiology, University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Eschenfelder, Christoph C" sort="Eschenfelder, Christoph C" uniqKey="Eschenfelder C" first="Christoph C" last="Eschenfelder">Christoph C. Eschenfelder</name><affiliation wicri:level="1"><nlm:affiliation>Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim</wicri:regionArea><wicri:noRegion>Ingelheim</wicri:noRegion><wicri:noRegion>Ingelheim</wicri:noRegion><wicri:noRegion>Ingelheim</wicri:noRegion></affiliation></author><author><name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A" last="Donnan">Geoffrey A. Donnan</name><affiliation wicri:level="4"><nlm:affiliation>Florey Neuroscience Institutes, University of Melbourne, Parkville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Florey Neuroscience Institutes, University of Melbourne, Parkville</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Leys, Didier" sort="Leys, Didier" uniqKey="Leys D" first="Didier" last="Leys">Didier Leys</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Roger Salengro Hospital, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Roger Salengro Hospital, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Molina, Carlos" sort="Molina, Carlos" uniqKey="Molina C" first="Carlos" last="Molina">Carlos Molina</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Hospital Vall d'Hebron-Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Vall d'Hebron-Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Ringleb, Peter A" sort="Ringleb, Peter A" uniqKey="Ringleb P" first="Peter A" last="Ringleb">Peter A. Ringleb</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schellinger, Peter D" sort="Schellinger, Peter D" uniqKey="Schellinger P" first="Peter D" last="Schellinger">Peter D. Schellinger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Johannes-Wesling-Medical-Centre Minden, Minden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Johannes-Wesling-Medical-Centre Minden, Minden</wicri:regionArea><wicri:noRegion>Minden</wicri:noRegion><wicri:noRegion>Minden</wicri:noRegion><wicri:noRegion>Minden</wicri:noRegion></affiliation></author><author><name sortKey="Schwab, Stefan" sort="Schwab, Stefan" uniqKey="Schwab S" first="Stefan" last="Schwab">Stefan Schwab</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University of Erlangen-Nuernberg, Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Erlangen-Nuernberg, Erlangen</wicri:regionArea><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Toni, Danilo" sort="Toni, Danilo" uniqKey="Toni D" first="Danilo" last="Toni">Danilo Toni</name><affiliation wicri:level="3"><nlm:affiliation>Emergency Department Stroke Unit, La Sapienza University Hospital, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Emergency Department Stroke Unit, La Sapienza University Hospital, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Wahlgren, Nils" sort="Wahlgren, Nils" uniqKey="Wahlgren N" first="Nils" last="Wahlgren">Nils Wahlgren</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Karolinska University Hospital-Solna, Solna, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurology, Karolinska University Hospital-Solna, Solna</wicri:regionArea><wicri:noRegion>Solna</wicri:noRegion></affiliation></author><author><name sortKey="Hacke, Werner" sort="Hacke, Werner" uniqKey="Hacke W" first="Werner" last="Hacke">Werner Hacke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author></analytic><series><title level="j">International journal of stroke : official journal of the International Stroke Society</title><idno type="eISSN">1747-4949</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intravenous</term><term>Clinical Protocols (standards)</term><term>Double-Blind Method</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Neuroimaging</term><term>Stroke (drug therapy)</term><term>Thrombolytic Therapy (methods)</term><term>Time Factors</term><term>Tissue Plasminogen Activator (administration & dosage)</term><term>Tissue Plasminogen Activator (therapeutic use)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral (traitement médicamenteux)</term><term>Activateur tissulaire du plasminogène (administration et posologie)</term><term>Activateur tissulaire du plasminogène (usage thérapeutique)</term><term>Administration par voie intraveineuse</term><term>Facteurs temps</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Méthode en double aveugle</term><term>Neuroimagerie</term><term>Protocoles cliniques (normes)</term><term>Résultat thérapeutique</term><term>Traitement thrombolytique ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Tissue Plasminogen Activator</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Activateur tissulaire du plasminogène</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Thrombolytic Therapy</term></keywords><keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Protocoles cliniques</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Clinical Protocols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Tissue Plasminogen Activator</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Accident vasculaire cérébral</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Activateur tissulaire du plasminogène</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intravenous</term><term>Double-Blind Method</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Neuroimaging</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie intraveineuse</term><term>Facteurs temps</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Méthode en double aveugle</term><term>Neuroimagerie</term><term>Résultat thérapeutique</term><term>Traitement thrombolytique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is an effective and approved therapy for acute ischemic stroke within 4.5 h of onset except for USA, Canada, Croatia, and Moldovia with a current 3 h label. We hypothesized that ischemic stroke patients selected with significant penumbral mismatch on magnetic resonance imaging (MRI) at 4.5-9 h after onset of stroke will have improved clinical outcomes when given intravenous rt-PA (alteplase) compared to placebo.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>France</li><li>Italie</li><li>Suède</li></country><region><li>Bade-Wurtemberg</li><li>Bavière</li><li>Catalogne</li><li>District de Karlsruhe</li><li>District de Moyenne-Franconie</li><li>Hauts-de-France</li><li>Latium</li><li>Nord-Pas-de-Calais</li><li>Victoria (État)</li></region><settlement><li>Barcelone</li><li>Erlangen</li><li>Heidelberg</li><li>Lille</li><li>Melbourne</li><li>Rome</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Amiri, Hemasse" sort="Amiri, Hemasse" uniqKey="Amiri H" first="Hemasse" last="Amiri">Hemasse Amiri</name></region><name sortKey="Bendszus, Martin" sort="Bendszus, Martin" uniqKey="Bendszus M" first="Martin" last="Bendszus">Martin Bendszus</name><name sortKey="Bluhmki, Erich" sort="Bluhmki, Erich" uniqKey="Bluhmki E" first="Erich" last="Bluhmki">Erich Bluhmki</name><name sortKey="Eschenfelder, Christoph C" sort="Eschenfelder, Christoph C" uniqKey="Eschenfelder C" first="Christoph C" last="Eschenfelder">Christoph C. Eschenfelder</name><name sortKey="Hacke, Werner" sort="Hacke, Werner" uniqKey="Hacke W" first="Werner" last="Hacke">Werner Hacke</name><name sortKey="Ringleb, Peter A" sort="Ringleb, Peter A" uniqKey="Ringleb P" first="Peter A" last="Ringleb">Peter A. Ringleb</name><name sortKey="Schellinger, Peter D" sort="Schellinger, Peter D" uniqKey="Schellinger P" first="Peter D" last="Schellinger">Peter D. Schellinger</name><name sortKey="Schwab, Stefan" sort="Schwab, Stefan" uniqKey="Schwab S" first="Stefan" last="Schwab">Stefan Schwab</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Donnan, Geoffrey A" sort="Donnan, Geoffrey A" uniqKey="Donnan G" first="Geoffrey A" last="Donnan">Geoffrey A. Donnan</name></region></country><country name="France"><region name="Hauts-de-France"><name sortKey="Leys, Didier" sort="Leys, Didier" uniqKey="Leys D" first="Didier" last="Leys">Didier Leys</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Molina, Carlos" sort="Molina, Carlos" uniqKey="Molina C" first="Carlos" last="Molina">Carlos Molina</name></region></country><country name="Italie"><region name="Latium"><name sortKey="Toni, Danilo" sort="Toni, Danilo" uniqKey="Toni D" first="Danilo" last="Toni">Danilo Toni</name></region></country><country name="Suède"><noRegion><name sortKey="Wahlgren, Nils" sort="Wahlgren, Nils" uniqKey="Wahlgren N" first="Nils" last="Wahlgren">Nils Wahlgren</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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